Beyond Inheritance: Our Ever-Mutating Cells and a New Understanding of Health

By Roxanne Khamsi “Constantly fascinating and impeccably reported...You won't look at yourself in the same way again.” —Ed Yong, bestselling author of An Immense World and I Contain Multitudes A captivating exploration of the remarkable ways our DNA mutates over the course of our lives, with radical implications for the future of medicine Our DNA is the indispensable set of instructions that guides our growth and vitality. The common misconception is that this molecular blueprint stays the same throughout our lives. In reality, the genetic makeup of our cells is continuously mutating, from the moment we are conceived until our last breath. The hidden changes that amass in our genomes can have a huge influence on our health. In this groundbreaking book, science writer Roxanne Khamsi describes our bodies as active landscapes of mutation. She reveals how the forces of Darwinian evolution operate within our own tissues. The effects can be devastating, such as when mutant blood cells outcompete their normal counterparts and increase the risk of heart attacks. But mutations can also make our bodies more resilient: Liver cells with genetic changes seem to cope better with excess calories. And immune cells with remixed DNA can make more effective antibodies against the microbes that threaten us. By letting go of the antiquated idea that every cell in a body has the same exact DNA, we can usher in a whole new era of medicine, including better vaccines and treatments that outsmart cancer. Beyond Inheritance will open your eyes to the immense genetic diversity that exists within you and its incredible potential to shape your well-being.

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